paclitaxelloaded dqasomes uj day after tumor implantation fig tumor growth inhibition study in nude mice implanted gatifloxacin eye drops safe with human colon cancer cells the mean tumor volume from each group was blotted against the number of days each group involved animals for clarity, error bars were omitted note that after weeks the dose, normalized for paclitaxel, was tripled in all treatment groups empty dqasomes do not show any impact on tumor growth, gatifloxacin eye drops safe paclitaxelloaded dqasomes with paclitaxel and dequalinium concentrations identical to controls seem to inhibit the tumor growth by about correspondingly, the average tumor weight in the treatment group, after sacrificing the animals days, later was approximately half of that in all controls although this result seems to suggest gatifloxacin eye drops safe that dqasomes might indeed be able gatifloxacin eye drops safe to increase the therapeutic potential of paclitaxel, the preliminary character of this first in vivo study has to be emphasized experiments to optimize the gatifloxacin eye drops safe treatment protocol are ongoing in the authors laboratory summary since their initial description in , dqasomes and dqasomelike vesicles have been established as the first mitochondriatargeted colloidal delivery system, capable of transporting plasmid dna as well as small drug molecules towards mitochondria within gatifloxacin eye drops safe living mammalian cells the further exploration of this unique mitochondriotropic delivery system will introduce new ways for gatifloxacin eye drops safe the treatment of cancer and for the therapy snort zyprexa of a multitude of mitochondrial diseases acknowledgments i am grateful gatifloxacin eye drops safe to prof v p torchilin for many helpful discussions and for his strong and continuous support of my work i also would like to sincerely thank my graduate students, gerard dsouza, shingming cheng, sarathi boddapati and gatifloxacin eye drops safe eyad katrangi, whose experimental work has made the writing of this chapter possible i am obliged to the muscular dystrophy association tucson, az, the gatifloxacin eye drops safe united mitochondrial disease foundation pittsburgh, pa, gatifloxacin eye drops safe mitovec, inc boston, ma and northeastern university boston, ma for the financial support i received from these organizations during the last four years references weissig v, lasch j, erdos g, meyer hw, rowe tc and hughes j dqasomes a novel potential drug and gene delivery system made from dequalinium pharm res � smith ra, porteous cm, gane am and murphy mp delivery of bioactive molecules gatifloxacin eye drops safe to mitochondria in vivo proc natl acad sci usa murphy mp and smith ra drug delivery to mitochondria the key to mitochondrial medicine adv drug del rev muratovska a, lightowlers gatifloxacin eye drops safe rn, taylor rw, wilce ia and murphy mp targeting large molecules to mitochondria adv drug del rev szewczyk a and wojtczak l mitochondria gatifloxacin eye drops safe as a pharmacological target pharmacol rev weissig v mitochondrialtargeted drug and dna delivery crit rev ther drug carr gatifloxacin eye drops safe syst weissig v, cheng sm and gatifloxacin eye drops safe dsouza g mitochondrial pharmaceutics mitochondrion weissig v targeted drug delivery to mammalian gatifloxacin eye drops safe mitochondria in living cells exp opin drug del weissig v, boddapati sv, dsouza ggm and cheng sm targeting of low molecular weight drugs to mammalian mitochondria drug des rev de rosa m, gambacorta a and gliozi a structure, biosynthesis, and physico chemical properties of archaebacterial lipids microbiol rev gambacorta a, gliozi a and de rosa m archaeal lipids and their biotechnological applications world j microbiol biotechnol weissig v, mogel hj, wahab gatifloxacin eye drops safe m and lasch j computer simulations of dqasomes proc intl symp control gatifloxacin eye drops safe rel bioact mater weissig v, lizano � and torchilin vp a micellar gatifloxacin eye drops safe delivery system for dequalinium � a lipophilic cationic drug with anticarcinoma activity gatifloxacin eye drops safe j lipos res weissig v, lizano c, ganellin cr and torchilin vp dna binding cationic bolasomes with delocalized charge center a structureactivity relationship study stp pharma sci chrzanowskalightowlers zm, lightowlers rn and turnbull dm gene therapy for mitochondrial dna defects is it possible?